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H.); Institute for Physiological Chemistry and Pathobiochemistry, Westfalian Wilhelms University, Münster, Germany (R. B.); Center for Accelerator Mass Spectrometry, Livermore, CA (B. Michael’s Hospital, Labatt Family Centre of Excellence in Brain Injury and Trauma Research, Keenan Research Centre of the Li Ka Shing Knowledge Institute of St. Although ruptured aneurysms are also frequently small, the low risk of rupture has stimulated an interest in the formation and progression of aneurysms and has sparked controversy about the time span over which aneurysms or their main component, collagen, might develop. 09–309); and Lawrence Livermore National Laboratory, Livermore, California (No. After informed consent, samples from aneurysm domes (3 mm) from 9 consecutive patients undergoing surgical treatment for a ruptured or unruptured aneurysm were surgically excised when feasible and kept frozen at −80° C until collagen extraction. From the Department of Neurosurgery, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany (N. The poor outcomes associated with aneurysm rupture support the treatment of unruptured aneurysms, but this is complicated by the low risk of rupture of small unruptured aneurysms. Michael’s Hospital, Department of Surgery, University of Toronto, Ontario, Canada (N. Although preliminary, our findings may have implications for the biological and structural stability of ruptured and unruptured intracranial aneurysms. H.); Institute for Physiological Chemistry and Pathobiochemistry, Westfalian Wilhelms University, Münster, Germany (R. B.); Center for Accelerator Mass Spectrometry, Livermore, CA (B. Michael’s Hospital, Labatt Family Centre of Excellence in Brain Injury and Trauma Research, Keenan Research Centre of the Li Ka Shing Knowledge Institute of St. The correlation of patient age and aneurysm FC levels could explain models of aneurysm development. but we have temporarily restricted your access to the Digital Library.Your activity appears to be coming from some type of automated process. From the Department of Neurosurgery, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany (N. Aneurysmal collagen was isolated and purified after pepsin digestion. F Conclusions—Our preliminary data suggest that collagen extracted from intracranial aneurysms generally has a high turnover, associated with aneurysm size and patient age. Michael’s Hospital, Department of Surgery, University of Toronto, Ontario, Canada (N. Methods—Aneurysmal domes from patients undergoing surgical treatment for ruptured or unruptured aneurysms were excised.

The restriction will be removed automatically once this activity stops. Most studies suggest that ruptured intracranial aneurysms undergo nonlinear growth or progression before rupture, suggesting that ruptured aneurysms have progressed relatively recently.This is supported by the high number of small aneurysms found after subarachnoid hemorrhage in epidemiological studies. Michael’s Hospital, Department of Surgery, University of Toronto, Ontario, Canada (N. One aneurysm was treated by trapping, allowing the excision of 2 larger samples, one of which was taken from the neck of the aneurysm (R3 and R7).

H.); Institute for Physiological Chemistry and Pathobiochemistry, Westfalian Wilhelms University, Münster, Germany (R. B.); Center for Accelerator Mass Spectrometry, Livermore, CA (B. Michael’s Hospital, Labatt Family Centre of Excellence in Brain Injury and Trauma Research, Keenan Research Centre of the Li Ka Shing Knowledge Institute of St. Between September 2009 and November 2011, 10 aneurysm domes (7 ruptured, 3 unruptured, mean aneurysm size 13±10 mm) were excised from 9 patients (mean age 63±12 years) who underwent surgical clipping.According to some of these models, the tissue should be older and more stable in unruptured aneurysms.

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